LifeGene—a large prospective population-based study of global relevance
Identifieur interne : 000766 ( new/Analysis ); précédent : 000765; suivant : 000767LifeGene—a large prospective population-based study of global relevance
Auteurs : Catarina Almqvist [Suède] ; Hans-Olov Adami [Suède, États-Unis] ; Paul W. Franks [Suède] ; Leif Groop [Suède] ; Erik Ingelsson [Suède] ; Juha Kere [Suède] ; Lauren Lissner [Suède] ; Jan-Eric Litton [Suède] ; Markus Maeurer [Suède] ; Karl Michaëlsson [Suède] ; Juni Palmgren [Suède] ; Göran Pershagen [Suède] ; Alexander Ploner [Suède] ; Patrick F. Sullivan [États-Unis] ; Gunnel Tybring [Suède] ; Nancy L. Pedersen [Suède]Source :
- European Journal of Epidemiology [ 0393-2990 ] ; 2011-01-01.
Descripteurs français
- Wicri :
- topic : épidémiologie.
English descriptors
Abstract
Abstract: Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18–45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants’ age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years.
Url:
- https://api.istex.fr/ark:/67375/VQC-KD60P5GQ-G/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087900
DOI: 10.1007/s10654-010-9521-x
Affiliations:
- Suède, États-Unis
- Caroline du Nord, East Middle Sweden, Massachusetts, Svealand
- Chapel Hill (Caroline du Nord), Stockholm, Uppsala
- Université d'Uppsala, Université de Caroline du Nord à Chapel Hill, Université de Stockholm
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ISTEX:D69D4F414337CEB1C730522FA7AD3D28855BC7FBLe document en format XML
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first="Juni" last="Palmgren">Juni Palmgren</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Mathematical Statistics, Stockholm University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName><orgName type="university">Université de Stockholm</orgName></affiliation></author><author><name sortKey="Pershagen, Goran" sort="Pershagen, Goran" uniqKey="Pershagen G" first="Göran" last="Pershagen">Göran Pershagen</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, 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Sullivan</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Tybring, Gunnel" sort="Tybring, Gunnel" uniqKey="Tybring G" first="Gunnel" last="Tybring">Gunnel Tybring</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Suède</country></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Epidemiology</title><title level="j" type="abbrev">Eur J Epidemiol</title><idno type="ISSN">0393-2990</idno><idno type="eISSN">1573-7284</idno><imprint><publisher>Springer Netherlands</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="2011-01-01">2011-01-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="67">67</biblScope><biblScope unit="page" to="77">77</biblScope></imprint><idno type="ISSN">0393-2990</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0393-2990</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biobank</term><term>Cohort study</term><term>Epidemiology</term><term>Population genetics</term><term>Prospective study</term><term>Questionnaires</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>épidémiologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18–45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants’ age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years.</div></front></TEI><affiliations><list><country><li>Suède</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>East Middle Sweden</li><li>Massachusetts</li><li>Svealand</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li><li>Stockholm</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li><li>Université de Caroline du Nord à Chapel Hill</li><li>Université de Stockholm</li></orgName></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Almqvist, Catarina" sort="Almqvist, Catarina" uniqKey="Almqvist C" first="Catarina" last="Almqvist">Catarina Almqvist</name></region><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name><name sortKey="Almqvist, Catarina" sort="Almqvist, Catarina" uniqKey="Almqvist C" first="Catarina" last="Almqvist">Catarina Almqvist</name><name sortKey="Almqvist, Catarina" sort="Almqvist, Catarina" uniqKey="Almqvist C" first="Catarina" last="Almqvist">Catarina Almqvist</name><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W." last="Franks">Paul W. Franks</name><name sortKey="Franks, Paul W" sort="Franks, Paul W" uniqKey="Franks P" first="Paul W." last="Franks">Paul W. Franks</name><name sortKey="Groop, Leif" sort="Groop, Leif" uniqKey="Groop L" first="Leif" last="Groop">Leif Groop</name><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name><name sortKey="Lissner, Lauren" sort="Lissner, Lauren" uniqKey="Lissner L" first="Lauren" last="Lissner">Lauren Lissner</name><name sortKey="Litton, Jan Eric" sort="Litton, Jan Eric" uniqKey="Litton J" first="Jan-Eric" last="Litton">Jan-Eric Litton</name><name sortKey="Maeurer, Markus" sort="Maeurer, Markus" uniqKey="Maeurer M" first="Markus" last="Maeurer">Markus Maeurer</name><name sortKey="Maeurer, Markus" sort="Maeurer, Markus" uniqKey="Maeurer M" first="Markus" last="Maeurer">Markus Maeurer</name><name sortKey="Michaelsson, Karl" sort="Michaelsson, Karl" uniqKey="Michaelsson K" first="Karl" last="Michaëlsson">Karl Michaëlsson</name><name sortKey="Palmgren, Juni" sort="Palmgren, Juni" uniqKey="Palmgren J" first="Juni" last="Palmgren">Juni Palmgren</name><name sortKey="Palmgren, Juni" sort="Palmgren, Juni" uniqKey="Palmgren J" first="Juni" last="Palmgren">Juni Palmgren</name><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name><name sortKey="Pershagen, Goran" sort="Pershagen, Goran" uniqKey="Pershagen G" first="Göran" last="Pershagen">Göran Pershagen</name><name sortKey="Ploner, Alexander" sort="Ploner, Alexander" uniqKey="Ploner A" first="Alexander" last="Ploner">Alexander Ploner</name><name sortKey="Tybring, Gunnel" sort="Tybring, Gunnel" uniqKey="Tybring G" first="Gunnel" last="Tybring">Gunnel Tybring</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name></region><name sortKey="Sullivan, Patrick F" sort="Sullivan, Patrick F" uniqKey="Sullivan P" first="Patrick F." last="Sullivan">Patrick F. Sullivan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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